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Alpha feto protein (AFP} is an oncofetal protein found at high concentration in fetal and maternal blood and also in patients with certain neoplastic and non neoplastic disorders. The AFP derived from the fetus can be detected in the maternal serum in concentration about 100-fold less in amniotic fluid. The association between high concentrations of AFP with open neural tube & confiemed by many researchers, AFP is a single chain sialyated glycoprotein composed of approximately 580 amino acid residues and 3 - % carbohydratesmolecular weight of AFP is 67,000 Daltons and Is a Negatively charged Protein with us
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