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Glocose-6-Phosphate Dehydrogenase know as G6PD is considered as the archetypical X-linked"housekeepoing" enzyme that is present in all cells, where it plays a key role in regulation of carbon flowthrough the pentose phosphate pathway. Specifically, the enzyme catalyses the first step of this pathwayleading to the production of pentose phosphates and reducing power in the form of NADPH for the reductive biosynthesis and maintenance of rebox state in the cell . Blood cells are at a canstant danger of damagedue to production of free radicals in the body . G6PD enyme helps to produce glutathione which fights with these free radicalsand protect the blood cell from damage . Deficiency of G6PD because of ' food or drug induced hemolysis' decrease the productin of glutathione thus exposing the blood cells to the free radicals produced . The deficiency may arise if the gene responsiblefor the production of G6PD ( on the X-chromosome) gets mutated .This further hapers the production of glutathione . The is the most commom 'RBC enzyme deficiency ' affecting approximately 0.5- 26% of the world 's population .
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